You can find this in the top left corner of your window. Open Outlook and click File in the menu bar.If you don’t see the words, “Connected to: Microsoft Exchange” at the bottom of your Outlook window, check out our article on how to set up out of office in Outlook with an IMAP/POP3 account. Note: The following steps are for users with a Microsoft Exchange account. Office replies on the Microsoft Outlook desktop app, go to File > Automatic How to Set Up an Out of Office Reply in the Outlook Desktop App Here’s how to set up an automatic out of office reply in the Microsoft Outlook desktop app and the web version. These automatic replies let people who email you know that you are not available to reply to their messages. If you’re going away on vacation, it’s very useful to set an automatic “out of office” reply for your emails.